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Related to alkylating agents: Antimetabolites
alkylating agents[
a group of synthetic compounds containing alkyl groups that combine readily with other molecules. Their action seems to be chiefly on the DNA in the nucleus of the cell, so that they are cell cycle phase nonspecific. They cross-link the strands of DNA, preventing its replication and the transcription of RNA; the major site of action is on the base guanine. They are primarily used in chemotherapy of cancer (see antineoplastic therapy). However, they do not damage malignant cells selectively, but also have a toxic action on normal cells; all killing occurs primarily in rapidly proliferating tissue. Locally they cause blistering of the skin and damage to the eyes and respiratory tract. Systemic toxic effects are nausea and vomiting, reduction in both leukocytes and erythrocytes, hemorrhagic tendencies, amenorrhea or impaired spermatogenesis, damage to the intestinal mucosa, and alopecia. Among the agents of this group used in therapy are busulfan, cyclophosphamide, ifosfamide, and thiotepa; the , melphalan, and mechlorethamine; and the , lomustine, and streptozocin. They may be carcinogenic in humans; some have been linked to bladder cancer and acute leukemia. However, the major benefits obtained in treating diseases such as lymphoma, Hodgkin's disease, breast cancer, and multiple myeloma far outweigh the risks of developing a second malignancy.
alkylating agentsagents that react with groups such as amino [NH2 ], carboxyl [COOH], hydroxyl [OH] and phosphate [PO4 ] groups, and replace them with alkyl groups, such as CH3, CH2 CH3 groups. They may act as MUTAGENS or as ANTIMICROBIAL AGENTS.Want to thank TFD for its existence? Tell a friend about us, add a link to this page, or visit the webmaster's page for free fun content. Does Multiclick Count As Click Dmg Ch2 4Link to this page:Does Multiclick Count As Click Dmg Ch2 1Does Multiclick Count As Click Dmg Ch2 2Comments are closed.
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